The main quest begins after the player is forced to flee Vault 101 when James leaves the vault, throwing it into anarchy and causing the paranoid Overseer to send his security force after the player. James frequently makes comments about the player character's deceased mother Catherine, and her favorite Bible passage, Revelation 21:6, which speaks of 'the waters of life'. The introductory sequence introduces the Lone Wanderer (player) to their character's father James, a doctor and scientist in Vault 101.
